imidazoline receptors

imidazoline receptors
Receptors for imidazolines such as agmatine and idazoxan that modulate sympathetic outflow in the brainstem. I1 is elevated on platelets and in brains of patients with depression. Also expressed on vascular smooth muscle where they may mediate inhibition of proliferation. Candidate protein for I1-receptor is 85 kD and upregulated by idazoxan and agmatine. I2 receptors have been proposed to have a role in modulating pain during acute inflammation.

Dictionary of molecular biology. 2004.

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  • NISCH — Nischarin Identifiers Symbols NISCH; FLJ14425; FLJ40413; FLJ90519; I 1; IRAS; KIAA0975 External IDs …   Wikipedia

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  • agmatine — (= 1 amino 4 guanidobutane) A metabolite of arginine via arginine decarboxylase, is metabolized to putrescine by agmatinase. Suppresses polyamine biosynthesis and polyamine uptake by cells by inducing antizyme. Binds to imidazoline receptors and… …   Dictionary of molecular biology

  • Idazoxan — Drugbox IUPAC name = 2 (2,3 dihydro 1,4 benzodioxin 2 yl) 4,5 dihydro 1H imidazole CAS number = 79944 58 4 CAS supplemental = ATC prefix = ATC suffix = ATC supplemental = PubChem = 54459 DrugBank = chemical formula = C=11 | H=12 | N=2 | O=2… …   Wikipedia

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  • clonidine — Centrally acting anti hypertensive agent that works by inhibiting activity of the sympathoexcitatory neurons that regulate arterial pressure. Considered to be a mixed agonist acting on both alpha 2 adrenoreceptors and imidazoline receptors (I1 R) …   Dictionary of molecular biology

  • Rilmenidine — drugbox IUPAC name = N (dicyclopropylmethyl) 4,5 dihydro 1,3 oxazol 2 amine CAS number = 54187 04 1 ATC prefix = C02 ATC suffix = AC06 PubChem = 68712 DrugBank = C=10|H=16|N=2|O=1 molecular weight = 180.247 g/mol bioavailability = protein bound …   Wikipedia

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